{ "_id": "6a10339bacfb0bcc41c9864a", "Package": "scDiffCom", "Type": "Package", "Title": "Differential Analysis of Intercellular Communication from\nscRNA-Seq Data", "Version": "1.2.0", "Authors@R": "c(\nperson(\"Cyril\", \"Lagger\", email = \"lagger.cyril@gmail.com\",\nrole = c(\"aut\", \"cre\"),\ncomment = c(ORCID = \"0000-0003-1701-6896\")\n),\nperson(\"Eugen\", \"Ursu\", email = \"ursu_eugen@hotmail.com\",\nrole = c(\"aut\")),\nperson(\"Anais\", \"Equey\", email = \"anais.equey@gmail.com\",\nrole = c(\"ctb\"))\n)", "Description": "Analysis tools to investigate changes in intercellular\ncommunication from scRNA-seq data. Using a Seurat object as\ninput, the package infers which cell-cell interactions are\npresent in the dataset and how these interactions change\nbetween two conditions of interest (e.g. young vs old). It\nrelies on an internal database of ligand-receptor interactions\n(available for human, mouse and rat) that have been gathered\nfrom several published studies. Detection and differential\nanalyses rely on permutation tests. The package also contains\nseveral tools to perform over-representation analysis and\nvisualize the results. See Lagger, C. et al. 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