Changes in version 1.2.0 (2025-10-14) - run_interaction_analysis() now uses seurat_layer argument instead of seurat_slot to be consistent with Seurat (>= 5.0.0) - Clean internal data dependencies and remove explicit call to SingleCellSignalR::LRdb - Fix broken links in README - Prepare for CRAN submission Changes in version 1.1.0 - Allow to use a custom LRI database Changes in version 1.0.0 (2023-11-03) 01-11-2023 - Prepare for CRAN release - Update links to the Nature Aging paper Changes in version 0.2.4 11-04-2023 - Change default red-green colors in plots - Improve README and website Changes in version 0.2.3 08-05-2022 - Remove mouse and rat LRIs with "homolog_orthology_confidence" of 0, but only if they are not already provided directly by one of the "source database" - Remove some miss-curated LRIs Changes in version 0.2.2 11-04-2022 - Compute (permutation-based) p-values and logFC for each ligand and receptor gene independently Changes in version 0.2.1 20-01-2022 - Fix a bug that appeared when 'seurat_object[[]]' contained a column named 'cell_id' Changes in version 0.2.0 24-11-2021 - New function BuildShiny() that creates a shiny app from the results - New function ReduceGO() to reduce GO terms by semantic similarity Changes in version 0.1.0.9000 09-11-2021 - A rat LRI database (LRI_rat) has been added (based on orthology conversion) - run_interaction_analysis() accepts rat as species parameter - LRI datasets have a reduced size - Dataset gene_ontology_level is now available as data (instead of internal data) Changes in version 0.1 04-07-2021 - All steps of run_interaction_analysis have been tested - All exported functions have been tested - LRI databases have been curated - Complete roxygen-based documentation - Vignette contains the main functionalities Changes in version 0.0.0.9000 - Added a NEWS.md file to track changes to the package. - Added the first proper documentation - Added the first version of the vignette